U.S. scientists have discovered a method of developing antibiotics that might be an important step in fighting drug-resistant infections.
The researchers at the University of Minnesota and University of Michigan say their approach, described as efficient and environmentally friendly, can help develop antibiotics that are needed to kill the increasing number of infections resistant to multiple drugs.
"We're striving to create new drugs that can have a positive impact on the growing threat of infectious diseases," said Robert Fecik, assistant professor of medicinal chemistry at the University of Minnesota College of Pharmacy and one of the lead authors of the study. "This type of research can help us make new antibiotic molecules."
The interdisciplinary team of scientists, including professors David Sherman and Janet Smith from the University of Michigan's Life Sciences Institute, is the first to crystallize an enzyme in the process of closing the antibiotic ring, which illustrates exactly how the ring is formed.
The research is described in two articles published in the current online issue of Nature Chemical Biology.
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